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Date Titre
25/12/2023

A cross-scale method for predicting equivalent elastic constants of needled C/SiC composite considering manufacturing defects

17/11/2023

Preparation of wood plastic composite from flax fibers and post consumed polystyrene foam based on environmental and economical scales

28/04/2022

[ASAP] Ultrasound-Responsive Peptide Nanogels to Balance Conflicting Requirements for Deep Tumor Penetration and Prolonged Blood Circulation

21/02/2022

Symmetry, Vol. 14, Pages 428: Important Study on the ∇ Dynamic Hardy–Hilbert-Type Inequalities on Time Scales with Applications

18/02/2022

Energies, Vol. 15, Pages 1520: Influence of Nanoparticles on the Degradation Processes of Ester-Based Transformer Insulation Systems

18/02/2022

[tel-03579271] Transformer pour comprendre les ressorts de la persévérance des enseignants du premier degré, dans des Espaces de Dons Encouragés : hybridation entre programme de recherche en Anthropologie Culturaliste et paradigme du Don

17/02/2022

Protocol for characterizing the molar mass distribution and oxidized functionality profiles of aged transformer papers by gel permeation chromatography (GPC)

14/02/2022

https://tel.archives-ouvertes.fr/tel-03569685 ano.nymous@ccsd.cnrs.fr.invalid (Marie-Gabrielle Duperron) Marie-Gabrielle Duperron Cerebral small vessel disease (cSVD) is a major cause of stroke, cognitive impairment and dementia. Magnetic resonance imaging (MRI) markers of cSVD comprise white matter hyperintensities (WMH), MRI-defined lacunes of presumed vascular origin (Lac), cerebral microbleeds (CMB) and dilated perivascular spaces (dPVS). A systematic review and meta-analysis on > 16,000 participants enabled to characterize the association of WMH, BI and CMB with risk of stroke and dementia, as well as their subtypes, and with mortality. Because of limited data on dPVS, we examined the longitudinal relationship of dPVS burden with incident stroke risk in the population-based 3C-Dijon study, and found a significant association between dPVS burden, especially in basal ganglia and hippocampus, and incident risk of any stroke and intracerebral hemorrhage. We then explored the heritability of dPVS burden using genome-wide genotypes and found highest heritability for dPVS burden compared with other MRI-markers of cSVD, especially in the white matter. Second we conducted a genome-wide association study (GWAS) meta-analysis of dPVS burden and identified two genome-wide significant loci associated with extensive dPVS burden in the white matter, implicated in brain development, brain vascular function and oncogenesis. We found significant genetic correlation of dPVS burden in basal ganglia with all stroke and ischemic stroke. Finally, we conducted an extension of this work in the Japanese Nagahama population-based study to: (i) compare the reproducibility of three dPVS visual rating scales (ii) conduct the first GWAS of WMH volume in a Japanese cohort, confirming the chr17q25.1 locus and identifying new loci associated with regional WMH volume. In conclusion, we provide novel information on the clinical significance of MRI-markers of cSVD, especially dPVS, and new insight into the genetic contribution to MRI-markers of cSVD, by conducting the first heritability assessment and GWAS meta-analysis of dPVS burden, and the first GWAS of WMH volume in a Japanese population.

09/02/2022

Cancers, Vol. 14, Pages 856: Chloride Channels and Transporters: Roles beyond Classical Cellular Homeostatic pH or Ion Balance in Cancers

07/02/2022

Sensors, Vol. 22, Pages 1248: Power Transformer Voltages Classification with Acoustic Signal in Various Noisy Environments

31/01/2022

Sports, Vol. 10, Pages 18: The Effect of a Handball Warm-Up Program on Dynamic Balance among Elite Adolescent Handball Players

27/01/2022

Pharmaceutics, Vol. 14, Pages 296: Thermodynamic Balance vs. Computational Fluid Dynamics Approach for the Outlet Temperature Estimation of a Benchtop Spray Dryer

25/01/2022

[ASAP] Universal Scaling for the Exit Dynamics of Block Copolymers from Micelles at Short and Long Time Scales

14/01/2022

[tel-03525201] Bipolar Electrochemistry for Generating Complex Asymmetric Objects at Different Length Scales

06/01/2022

Preparation of highly dispersed ZnO nanoparticles to fabricate ultraviolet-shielding poly(vinyl chloride) films

Enregistrements: 711 - Nº Pages: 48